At our research labs, we are at the forefront of pioneering research into measuring the accumulation of antibiotics within bacteria. Our team is dedicated to unraveling the complexities of antibiotic resistance and developing novel approaches to combat it. We are committed to driving innovation and making a meaningful impact in the field of antibiotic research.

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Establishing a high-throughput screening method to analyze how chemical structures influence the accumulation of molecules within bacterial cells is crucial in the fight against drug-resistant bacterial infections. One of the primary challenges in treating these infections, especially those caused by diderm pathogens, is the bacteria's ability to prevent antibiotics from penetrating their defenses and reaching intracellular targets. This impermeability, largely due to the unique structure of their outer membranes, is a significant barrier to effective treatment.

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Co-Directors:

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Marcos Pires - University of Virginia

Sloan Siegrist - University of Massachusetts